|
KMID : 0385219960060020022
|
|
Korean Journal of Gerontology
1996 Volume.6 No. 2 p.22 ~ p.27
|
|
|
Dietary restriction as a Modulator of Age-related Changes in Prostaglandin Biosynthesis in Rat Kidney Microsomes
|
|
Choi Jin-Ho
Yu Byung-Pal
|
|
|
Abstract
|
|
|
|
Dietary restriction in rats (DR) began at 6 weeks old, and consisted of 60% of the daily caloric allowance of the ad libitum-fed rats (AL). The effects of age and DR on prostaglandin (PG) and thrombozane (TX) syntheses in kidney microsome of rats were investigated in the evaluation of renal function. Arachidonic acid contents in kidney microsome of DR rats were slightly lower than those of AL rats, while linoleic acid contents in kidney microsome of DR rats were consistently 12∼25% higher than those of AL fed rats. PGE2 levels of DR rats were consistently 15∼20% higher than those of AL rats until 18 months of age but acute increases in PGE2 showed in aged AL rats of 24 months of age, suggesting that renal blood flow (REF) in AL rats inhibits with age. PGF2α levels of DR rats were consistently 13∼20% higher than those of AL rats. PGI2 levels in aged DR rats were 16∼32% higher than those of AL rats, while TXA2 levels in aged DR rats were significantly 32∼142% lower than those of AL rats. PGI2/TXA2 ratios of DR rats were consistently 1.2∼2.2 times higher than those of AL rats. Therefore, DR is the most efficient means of maintaining homeostatic balance through RBF.
|
|
|
KEYWORD
|
|
|
dietary restriction (DR), prostaglandin (PG), thromboxane (TX), PGE2, PGI2, TXA2, PGF2α Kidney microsomes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|